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Vivek Chakravarthy (Manoj Manchu) is an upcoming rock star in Bengaluru who hails from a family of decorated army officers. His mother wants him to follow the same path but he isn't interested. He is about to give his first live concert on New Year's Eve with his band-mates in Hyderabad. However, Vivek is late to catch the flight and so the band is forced to travel by road. After sometime, one of their tyres get deflated. Not having a spare, the other friends go to get the tyre inflated leaving Vivek and Lasya (Lekha Washington) alone. Meanwhile,they are attacked by a Hindu fanatic group. However, they manage to get out of the mess with the help of a Sikh truck driver (who incidentally gets involved in an earlier altercation with Vivek). The band successfully reaches Hyderabad. However they suffer a minor accident there which involves a mother in labour. So Vivek and Lasya take her to a hospital nearby.
Saroja (Anushka) is a prostitute in Amalapuram working for Rattamma. She has a best friend Karpooram who is a eunuch. Saroja doesn't like working for Rattamma and plans to run away from there. Her dreams come true when she receives a call from Hyderabad from one of her agents. The very next day, which happens to be the New Year's Eve, she leaves for Hyderabad with Karpooram, without Rattamma's knowledge; but not before putting the local sub-inspector Bullabbai to sleep using pills. However, Saroja is arrested in Hyderabad by constables for betraying Bullabbai. Karpooram frees her from the inspector and they are both taken by their agent to a client. The client turns out to be yet another broker, who bought Saroja and Karpooram from Rattamma. Both successfully escape from the broker after a scuffle in which Karpooram gets stabbed. So, Saroja takes her to the same hospital that Vivek and Lasya take the pregnant lady to.
Ramulu (Nagayya) is a debt-ridden weaver from Sircilla. He lives with his widowed daughter-in-law, Padma (Saranya Ponvannan) and grandson. Ramulu is desperate to get his grandson educated, being illiterate himself. However he owes money to the local landlord, who takes his grandson away saying that he would be sent to the construction business in the city for 11 years to recover the money. He gives Ramulu and Padma 3 days to clear the debt. Not knowing what to do, Padma agrees to sell her kidney, which is illegal (Ramulu had previously sold his kidney for the same purpose). They come to Hyderabad and her kidney is sold successfully in the hospital where the other characters are. The original kidney is sold for ₹1,00,000 of which Ramulu gets only ₹37,000.
Rahimuddin Qureshi (Manoj Bajpayee) is a Muslim hailing from Old Basti in Hyderabad. In the past, his wife suffered a miscarriage due to a scuffle between him and a few Ganesh devotees during a religious procession. Unable to bear the loss, he decides to leave the country. However, during his farewell party, Shivaram (Ravi Prakash) (who previously insulted Rahim during the scuffle) comes to his house and arrests his nephews, alleging that they have links with terrorists. When Rahim obstructs him, he arrests him too. During interrogation, one of his nephews accepts his terrorist background and says that something tragic would happen on New Year's Eve. Rahim is shocked. When the police transports him to remand, Rahim panics and tries to escape. However, his escape bid is unsuccessful and he gets shot in the leg. He is then taken to the same hospital as the rest of the characters are in and kept in the same ward as another terrorist suspect.
Cable Raju (Allu Arjun) is a lower middle class guy hailing from Jubilee Hills slum living with his maternal grandmother. He loves Pooja (Deeksha Seth), who is from the upper class of the society. Pooja, however, doesn't know of Raju's financial background and thinks of him to be rich. Raju has to get 2 passes for a lavish New Year's Eve party which cost almost ₹40,000. He tries to obtain that money by various means, but is unsuccessful. In desperation, he tries to snatch chains from women's necks, but is apprehended by the police when his motorbike hits a police van. He is taken to the police station where he meets Saroja. However, Dappu Subani (Raghu Babu) (who initiated him into the chain snatching business) comes to his rescue and gets him freed. His grandmother, vexed at his behaviour, gives him 3,000 rupees and asks him to do whatever he wants. In a local cafeteria, he happens to see Ramulu with his money bundle and decides to steal it and thus follows him to the hospital. He successfully manages to steal the bundle from Ramulu and Padma. However, as he is about to pay for the passes, he realizes his mistake, adds his own 3,000 rupees to the bundle and returns it to Ramulu at the hospital.
Meanwhile, a group of terrorists come to the ward housing Rahim and free their leader. They leave Rahim unharmed on account of him being a Muslim and start the terrorist attack. Raju and Vivek try to save as many people as possible. They even kill two terrorists in the process. Rahim saves Shivaram's life. In the final fight sequence, both Raju and Vivek valiantly give up their lives, trying to protect the people in the hospital.
The conclusion of the movie shows Saroja deciding to change her profession; Vivek being dead but recognized as a national hero; Raju was dead being respected by all in his community, with Pooja coming to see him along with her mother; Rahim being freed by Shivaram; and Ramulu successfully repaying the money and getting his grandson back.
